Wayne, Pennsylvania, USA —To improve detection and reporting of antimicrobial resistance, the Clinical and Laboratory Standards Institute (CLSI) has published a revised edition of its annual supplement providing revised breakpoints, new testing recommendations, and reporting changes needed to incorporate into routine practice.
The document, titled Performance Standards for Antimicrobial Susceptibility Testing (M100, 27th ed.), provides updated tables for the CLSI antimicrobial susceptibility testing (AST) standards Performance Standards for Antimicrobial Disk Susceptibility Tests (M02-Ed12), Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria That Grow Aerobically (M07-Ed10), and Methods for Antimicrobial Susceptibility Testing of Anaerobic Bacteria (M11-Ed8). Clinicians rely on information from the microbiology laboratory to treat their patients. Due to the importance of AST results, these tests need to be performed under optimal conditions and laboratories must be capable of providing results for the newest antimicrobial agents. Using procedures standardized in M02, M07, and M11, M100 includes the essential data for drug selection, interpretation, and QC needed for clinical practice.
“The most recent edition of M100 includes multiple updates that clarify AST recommendations, but three new recommendations are really critical for detecting resistance in two of the Centers for Disease Control and Prevention’s urgent antibiotic resistance threats: carbapenemase-producing Enterobacteriaceae and drug-resistant Neisseria gonorrhoeae,” states Dr. Jean B. Patel, PhD, D(ABMM), Centers for Disease Control and Prevention, Atlanta, Georgia, USA and Chairholder of the Subcommittee on Antimicrobial Susceptibility Testing,. “Specifically, the following information was added:
Major changes to this edition of M100 include the following:
QC ranges were added and/or changed for the following drugs and organisms:
For more information about M100, contact Patrick McGinn at firstname.lastname@example.org or +1.484.588.5933.
CLSI sets the standard for quality in medical laboratory testing. A not-for-profit membership organization, CLSI brings together the global laboratory community for the advancement of a common cause: to foster excellence in laboratory medicine.
For nearly 50 years, our members, volunteers, and customers have made CLSI a respected, transformative leader in the development and implementation of medical laboratory testing standards. Through our unified efforts, we will continue to set and uphold the standards that drive quality test results, enhance patient care delivery, and improve health care around the world.
By using CLSI standards, laboratorians can improve process quality, speed the development of standard operating procedures, and implement safer practices with greater ease and efficiency.